9/18/2023 0 Comments Norma pro 4 39 serialiThus, Als3 potentiates targeting of candidalysin, and both Als3 and candidalysin are required for C. albicans hypha leads to the formation of an endocytic vacuole where candidalysin accumulates at high concentration. We found that EGFR and EphA2 constitutively associate with each other as part of a heteromeric physical complex and are mutually dependent for C. Here, we investigated the interactions among EphA2, EGFR, Als3 and candidalysin during OPC. albicans and is known to be activated by the Als3 adhesin/invasin and the candidalysin pore-forming toxin. The epidermal growth factor receptor (EGFR) also interacts with C. The ephrin type-A receptor 2 (EphA2) detects β-glucan and plays a central role in stimulating epithelial cells to release proinflammatory mediators during OPC. During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
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